Exploring antibacterial and cytotoxic potential of endophytic Streptomyces isolated from the medicinal plant Litsea cubeba (Lour.) Pers

In the past decades, researchers and scientists have paid increasing attention to discover novel antibiotics anticancer agents in combating infection cancer diseases. It is believed that endophytic actinomycetes from medicinal plants provide a resourful niches for new compounds with significant bioactive properties. present study, we first time assessed antibacterial cytotoxic activities of associated Litsea cubeba (Lour.) Pers. A total 25 were isolated Pers collected at Lai Chau province, Vietnam, maximum number isolates obtained roots (44.4%), followed by stems (35.5%), leaves (20.1%). Among them, 3 LCL08, LCL25, LCL28 showed broad spectrum activity against six pathogenic bacteria, which subsequently identified as Streptomyces albogriseolus S. olivaceus cavourensis using 16S rRNA sequence analysis. This report alborgriseolus endophyte. Ethyl acetate extracts strains exhibited strong 6 tested pathogens minimum inhibitory concentration value ranging 2-64 μg/ml. Moreover, these remarkable effects Hep3B human hepatoma, MCF-7 breast cancer, A549 lung cell lines recorded viability cells 13.87 65.69%. These findings suggest spp. recovered are an excellent source natural could be promising further research.